| AF131784在胃癌和胃癌前病变组织中的表达及临床意义 |
| 投稿时间：2016-01-16 修订日期：2016-01-29 点此下载全文 |
| 引用本文：李琪儿,叶国良,郭俊明.AF131784在胃癌和胃癌前病变组织中的表达及临床意义[J].医学研究杂志,2016,45(12):66-69 |
| DOI：
10.11969/j.issn.1673-548X.2016.12.018 |
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| 基金项目:宁波市自然科学基金资助项目（2013A610206）；宁波市医学科技计划项目（2013A18） |
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| 中文摘要:目的 研究AF131784在胃癌组织和癌前病变组织中的表达情况并探讨其对胃癌诊断的临床意义。方法 应用实时定量反转录聚合酶链反应（qRT-PCR）技术检测134例组织样本（包括104例胃癌组织和30例胃黏膜异型增生组织）中AF131784的表达量。结果 AF131784在胃癌组织中的表达量较成对的癌旁组织降低2.1倍（P=0.000）。AF131784在早期胃癌组织及胃黏膜异型增生组织中的表达量也显著降低。结论 AF131784在胃癌的发生中可能起重要作用，并且有可能成为胃癌早期筛查的肿瘤生物学标志物。 |
| 中文关键词:AF131784 胃癌 异型增生 肿瘤标志物 |
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| Expression of AF131784 in Gastric Cancer and Gastric Premalignant Lesions and Its Clinical Significance |
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| Abstract:Objective To understand the expression and clinical significance of AF131784 in gastric cancer and gastric premalignant lesions.Methods AF131784 expression in 134 samples containing 104 gastric cancer tissues and 30 gastric epithelial dysplasia tissues were detected using quantitative reverse transcription-polymerase chain reaction (qRT-PCR).Results AF131784 was down regulated in gastric cancer tissues with a more than two-fold lower level compared to paired adjacent normal tissues (P=0.000). More importantly, AF131784 was also significantly down regulated in early gastric cancer and gastric epithelial dysplasia tissues.Conclusion AF131784 may play an important role in gastric cancer initiation and also a potential use of AF131784 as a tumor biomarker for screening patients with early gastric cancer. |
| keywords:AF131784 Gastric cancer Epithelial dysplasia Tumor marker |
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