慢性阻塞性肺疾病急性加重患者血清sTREM-1水平及其临床诊断价值研究
投稿时间:2016-05-25  修订日期:2016-05-25  点此下载全文
引用本文:陈玺卿,杨玉波,庄志雄,付言杰,吕丽辉.慢性阻塞性肺疾病急性加重患者血清sTREM-1水平及其临床诊断价值研究[J].医学研究杂志,2017,46(1):154-159,163
DOI: 10.11969/j.issn.1673-548X.2017.01.041
摘要点击次数: 1055
全文下载次数: 765
作者单位E-mail
陈玺卿 315040 宁波, 中国人民解放军第113医院呼吸与重症医学科  
杨玉波 315040 宁波, 中国人民解放军第113医院呼吸与重症医学科  
庄志雄 315040 宁波, 中国人民解放军第113医院呼吸与重症医学科  
付言杰 315040 宁波, 中国人民解放军第113医院呼吸与重症医学科  
吕丽辉 315040 宁波, 中国人民解放军第113医院呼吸与重症医学科 lvlihui1979@sina.com 
中文摘要:目的 探讨慢性阻塞性肺疾病急性加重(acute exacerbation of chronic obstructive pulmonary disease,AECOPD)患者的血清可溶性髓细胞触发受体-1(souble triggering receptor expressed on myeloid cells-1,sTREM-1)水平及其诊断AECOPD的临床价值。方法 纳入2012年2月~2015年10月就诊的AECOPD患者70例,同时纳入稳定COPD患者44例(稳定COPD组)及健康人33例(健康对照组)作为对照。首次就诊时记录患者一般情况并检测呼吸功能,同时检测外周血sTREM-1水平、C反应蛋白(c-reactive protein,CRP)及降钙素原(procalcitonin,PCT)水平。结果 AECOPD组sTREM-1水平显著高于sCOPD组及健康对照组,差异有统计学意义(P<0.05)。AECOPD组患者治疗前sTREM-1水平显著高于治疗后,差异有统计学意义(P<0.05)。AECOPD组患者血清sTREM-1与CRP(r=0.674,P=0.000)、PCT(r=0.616,P=0.000)、WBC(r=0.648,P=0.000)及呼吸功能GOLD分级(r=0.454,P=0.000)呈显著正相关;sTREM-1水平与PO2r=-0.363,P=0.002)、FEV1%(r=-0.489,P=0.000)呈显著负相关。血清sTREM-1单独诊断AECOPD的AUC为0.793(95% CI:0.717~0.868),sTREM-1联合CRP及PCT诊断AECOPD的AUC为0.830(95% CI:0.762~0.898)。结论 AECOPD患者血清Strem-1水平可出现显著增高,且与呼吸功能损害严重程度相关。STREM-1可作为AECOPD诊断的候选指标,且联合CRP及PCT可进一步改进诊断效能。
中文关键词:慢性阻塞性肺疾病急性加重  可溶性髓细胞触发受体-1  C反应蛋白  降钙素原  诊断
 
Serum sTREM-1 Level in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease and Its Clinical Diagnostic Value
Abstract:Objective To investigate the serum souble triggering receptor expressed on myeloid cells-1 (sTREM-1) level in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and its clinical value. Methods A total of 70 patients with AECOPD from February 2012 to October 2015 were enrolled, and 44 patients with stable COPD (stable COPD group) and 33 healthy people (control group) were enrolled as control. General situations and pulmonary function were recorded. The sTREM-1, C-reactive protein (CRP) and procalcitonin (PCT) levels were detected. Results The sTREM-1 level in AECOPD group was significantly higher than sCOPD group and control group. sTREM-1 level in pre-treatment patients was significantly higher than pro-treatment. In AECOPD group, sTREM-1 was significantly positively associated with CRP (r=0.674, P=0.000), PCT (r=0.616, P=0.000), WBC (r=0.648, P=0.000) and GOLD grade (r=0.454, P=0.000), and was negatively associated with PO2 (r=-0.363, P=0.002), FEV1% (r=-0.489, P=0.000). AUC of sTREM-1 for AECOPD diagnosis was 0.793 (95%CI:0.717-0.868), and AUC of sTREM-1 combined with CRP and PCT was 0.830 (95%CI:0.762-0.898). Conclusion There is an elevated serum sTREM-1 level in AECOPD patients, which is associated with severity of respiratory function. The sTREM-1 is a candidate for AECOPD diagnosis, which could be improved by combining with CRP and PCT.
keywords:Acute exacerbation of chronic obstructive pulmonary disease  Souble triggering receptor expressed on myeloid cells-1  C-reactive protein  Procalcitonin  Diagnosis
查看全文  查看/发表评论  下载PDF阅读器

京公网安备 11010502037822号