| 脑靶向紫杉醇纳米胶束的体外实验研究 |
| 投稿时间：2016-11-21 修订日期：2016-11-29 点此下载全文 |
| 引用本文：陆恒,王雅杰.脑靶向紫杉醇纳米胶束的体外实验研究[J].医学研究杂志,2017,46(5):55-59 |
| DOI：
10.11969/j.issn.1673-548X.2017.05.015 |
| 摘要点击次数: 986 |
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| 基金项目:上海市自然科学基金资助项目（13NM1401504） |
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| 中文摘要:目的 研发一种新型的治疗乳腺癌脑转移的靶向递药系统。方法 采用薄膜水化法制备载药胶束，将胶束与脑靶向分子Angiopep-2连接，使胶束具有脑靶向功能。结果 体外细胞实验证实该胶束具有良好的靶向性。结论 连接有靶向分子Angiopep-2的纳米胶束具有良好的脑靶向功能。 |
| 中文关键词:乳腺癌 脑转移 纳米 靶向 胶束 |
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| Brain Targeting Drug Nano Micelle in Vitro Experimental Study |
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| Abstract:Objective To develop a novel targeted delivery system for the treatment of brain metastases from breast cancer. Methods Micelles were prepared by membrane hydration method, and the micelles were connected to Angiopep-2. Results The micelles were confirmed to be well targeted in vitro. Conclusion Nano-particles with the targeting molecule Angiopep-2 has good brain-targeting function. |
| keywords:Breast cancer Brain Metastases Nano Targeting Micelles |
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