免疫型肠内营养治疗高脂血症性急性胰腺炎的临床研究
投稿时间:2016-10-31  修订日期:2016-11-29  点此下载全文
引用本文:刘博.免疫型肠内营养治疗高脂血症性急性胰腺炎的临床研究[J].医学研究杂志,2017,46(7):75-78
DOI: 10.11969/j.issn.1673-548X.2017.07.018
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作者单位E-mail
刘博 056008 邯郸市中心医院东区急诊外一科 310655366@qq.com 
基金项目:河北省邯郸市科学技术研究与发展计划项目(1623208063-5)
中文摘要:目的 探讨免疫型肠内营养支持治疗高脂血症性急性胰腺炎的临床疗效、营养指标及免疫指标的变化。方法 选取笔者医院普外科2012年1月~2015年12月收治的高脂血症性急性胰腺炎患者100例,随机分为观察组和对照组各50例。两组患者入院后均给予急性胰腺炎规范化治疗,包括生命体征监测、禁食禁水、胃肠减压、抗炎、抑酸抑酶、维持水电解质及酸碱平衡等治疗。待患者肠功能恢复后,两组均给予肠内营养支持治疗,其中观察组给予添加免疫增强组件的免疫型肠内营养支持。经治疗10天后,比较两组患者疗效、APACHE-Ⅱ评分、营养指标(ALB和PAB)及免疫指标(TLC、IgA、IgG与IgM)变化情况。结果 两组患者给予不同的肠内营养液治疗后,观察组的疗效优于对照组(P<0.05)。治疗10天后各项检测指标均有明显改善,观察组APACHE-Ⅱ评分下降优于对照组(t=3.311,P<0.05);观察组ALB、PAB水平显著高于对照组(t=2.217、6.622,P<0.05);观察组TLC、IgA、IgG、IgM改善明显优于对照组(t=3.600、4.867、3.270、3.911,P<0.05)。结论 给予免疫型肠内营养支持治疗高脂血症性急性胰腺炎能改善患者营养状况、增强免疫功能,从而改善预后,达到提高临床疗效的目的。
中文关键词:高脂血症性急性胰腺炎  免疫型肠内营养  免疫功能  营养指标
 
Clinical Study on Effects of Enteral Immunonutrition in Patients with Hyperlipidemic Acute Pancreatitis
Abstract:Objective To discuss the clinical effects of enteral immunonutrition on patients with hyperlipidemic acute pancreatitis and its influence on levels of immunologic function and nutrition indicators. Methods 2015,100 patients with hyperlipidemic acute pancreatitis Selected from department of general surgery between January 2012 and December were randomly divided into observation group and control group, and each group had 50 cases. All patients were treated with conventional treatment, monitored for vital signs, fasting water, gastrointestinal decompression, anti-infection,acid suppression therapy and suppression of trypsin activity,balance of water electrolyte and acid-basewere included. After bowel function in patients with recovery, two groups were given enteral nutrition support, observation group were received enteral immunonutrition therapy.At the same time, we added the immune enhancement components.After treatment for 10 days,we compare two groups of patients with therapeutic effect, for APACHE-Ⅱ score, nutrition indicators(ALB, PAB),immune index(TLC,IgA,IgG,IgM) changes. Results After two groups of patients were given different enteral nutrient solution,the clinical total effective rate of observation group was obviously higher than that of control group(P<0.05). After treatment for 10 days, the indicators were obviously improved.The APACHE-Ⅱ score of the observation group were significantly fallinger than that of the control group (t=3.311,P<0.05). The ALB and PAB levels of the observation group were significantly higher than those of the control group (t=2.217, 6.622,P<0.05).At the same time,the TLC,IgA,IgG,IgM of the observation group were improved significantly better than the control group(t=3.600, 4.867,3.270,3.911,P<0.05). Conclusion Enteral immunonutrition can improve the nutrition indicators and immunological function of patients with hyperlipidemic acute pancreatitis, thus improve prognosis and promoting recovery of the patient.
keywords:Hyperlipidemic acute pancreatitis  Enteral immunonutrition  Immunologic function  Nutrition indicators
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