人脑胶质瘤中miR221的表达与预后关系的Meta分析
投稿时间:2017-01-19  修订日期:2017-02-21  点此下载全文
引用本文:张志勇,张晋霞,李林,付爱军,杨峰.人脑胶质瘤中miR221的表达与预后关系的Meta分析[J].医学研究杂志,2017,46(10):81-83
DOI: 10.11969/j.issn.1673-548X.2017.10.021
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作者单位
张志勇 063000 唐山, 华北理工大学附属医院神经外科 
张晋霞 063000 唐山, 华北理工大学附属医院神经外科 
李林 063000 唐山, 华北理工大学附属医院神经外科 
付爱军 063000 唐山, 华北理工大学附属医院神经外科 
杨峰 063000 唐山, 华北理工大学附属医院神经外科 
基金项目:河北省医学科学研究重点项目(20160739)
中文摘要:目的 采用Meta方法对人脑胶质瘤中miR221的表达与预后的关系进行分析。方法 分别采用"人脑胶质瘤"、"miR221"、"预后"、"miR221 "and" glioma "or" glioblastoma "and" prognosis"作为中文检索词和英文检索对2000年1月~2016年12月间中国知网数据库(CNKI)、万方数据库、超星数据库、维普数据库等中文数据库、Web of Science、PubMed等英文数据库进行检索。按照文献纳入和排除标准筛选入选文献,对文献质量进行评价,提取文献中相关数据资料,使用RevMan 5.2.3对纳入文献进行Meta分析。结果 最终纳入5篇符合的研究,共计442例人脑胶质瘤患者,对纳入研究的基本特征和治疗进行统计分析,显示具有较高质量,胶质瘤中miR221的表达与患者的总生存期呈负相关性(HR=1.15,95% CI:0.97~1.69,P=0.005)。结论 miR-221的表达量与患者预后生存期呈负相关性,miR-221的表达量可以独立作为胶质瘤患者的预后因素。
中文关键词:脑胶质瘤  miR221  预后  Meta分析
 
Meta Analysis of the Relationship between the Expression of miR221 and Prognosis in Human Gliomas
Abstract:Objective To evaluated the relationship between the expression of miR221 and the prognosis of human glioma by Meta method. Methods Were searched for Chinese words and English from January 2000 to December 2016 using "human glioma", "miR221", "prognosis", "miR221" and "glioma" or "glioblastoma" and "prognosis" (CNKI), Wanfang database, superstar database, VIP database and other Chinese databases, Web of Science, PubMed and other English databases for retrieval. The literatures were selected according to the inclusion and exclusion criteria, and the quality of the literature was evaluated. Meta-analysis of the included articles was performed using RevMan 5.2.3. Results A total of 442 patients with gliomas were included in the 5 eligible studies. Statistical analysis of the underlying characteristics and treatment of the included studies revealed a high quality of expression of miR221 in gliomas and overall patient survival Negative correlation (HR=1.15, 95% CI:0.97-1.69, P=0.005). Conclusion The expression of miR-221 was negatively correlated with the prognosis of patients. The expression of miR-221 could be independent prognostic factors in glioma patients.
keywords:Glioma  MiR221  Prognosis  Meta analysis
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