| 血浆M2-PK与血清CEA、ADAM8联合检测诊断非小细胞肺癌的临床价值研究 |
| 投稿时间：2017-01-02 修订日期：2017-02-14 点此下载全文 |
| 引用本文：王琼,吕秋琼,尉理梁.血浆M2-PK与血清CEA、ADAM8联合检测诊断非小细胞肺癌的临床价值研究[J].医学研究杂志,2017,46(10):187-189,142 |
| DOI：
10.11969/j.issn.1673-548X.2017.10.046 |
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| 中文摘要:目的 研究血浆M2型丙酮酸激酶（M2-PK）、血清肿瘤标志物癌胚抗原（CEA）和血清解整合素样-金属蛋白酶8（ADAM8）检测在诊断非小细胞肺癌（non-small cell lung cancer，NSCLC）中的应用价值。方法 随机选择2014年4月~2016年8月期间笔者医院收治的75例NSCLC患者作为研究组，另外随机选择75例笔者医院健康的体检者作为对照组。采用酶联免疫吸附法（ELISA）检测所有研究对象患者的血清ADAM8和M2-PK水平，使用电化学发光法（ECLIA）检测所有研究对象的血清CEA水平。并使用ROC曲线分析比较M2-PK、CEA和ADAM8单独和联合检测诊断NSCLC的临床价值。结果 研究组患者M2-PK、CEA和ADAM8水平均显著高于对照组，差异有统计学意义（P < 0.05）。腺癌组患者M2-PK、CEA水平明显高于鳞癌组患者，Ⅲ~Ⅳ期患者的M2-PK、CEA和ADAM8水平均明显高于Ⅰ~Ⅱ期患者，差异有统计学意义（P < 0.05）。M2-PK、CEA、ADAM8联合检测诊断NSCLC的AUC （0.924）明显高于M2-PK、CEA、ADAM8单独检测（0.731、0.858、0.790），差异有统计学意义（P < 0.05）。M2-PK、CEA和ADAM8联合检测NSCLC的敏感度和特异性均明显高于M2-PK、CEA和ADAM8单独检测组，差异有统计学意义（P < 0.05）。结论 M2-PK、CEA、ADAM8检测诊断NSCLC具有一定的临床应用价值，且M2-PK、CEA、ADAM8联合检测诊断价值优于单独检测，值得临床推广使用。 |
| 中文关键词:非小细胞肺癌 M2型丙酮酸激酶 肿瘤标志物癌胚抗原 解整合素样-金属蛋白酶8 |
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| Value of Combined Determination of Plasma M2-PK, Serum CEA and ADAM8 in the Diagnosis of Non-small Cell Lung Cancer |
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| Abstract:Objective To study the clinical application value of plasma M2 pyruvate kinase (M2-PK), serum tumor marker carcinoembryonic antigen (CEA) and serum level of integrin-like protein-8 (ADAM8) in the diagnosis of Non-small cell lung cancer (NSCLC). Methods Seventy-five patients with NSCLC admitted to our hospital from April 2014 to August 2016 were randomly selected as study group. Seventy-five healthy subjects were randomly selected as control group. Serum ADAM8 and M2-PK levels were measured by enzyme-linked immunosorbent assay (ELISA) in all subjects, and serum CEA levels were determined by electrochemiluminescence (ECLIA). The clinical value of M2-PK, CEA and ADAM8 in diagnosis of NSCLC were analyzed by ROC curve. Results The levels of M2-PK, CEA and ADAM8 in the study group were significantly higher than those in the control group (P<0.05). The levels of M2-PK and CEA in patients with adenocarcinoma were significantly higher than those in squamous cell carcinoma patients (P<0.05), and the levels of M2-PK, CEA and ADAM8 in stage Ⅲ-Ⅳ patients were significantly higher than those in stage Ⅰ-Ⅱ patients (P<0.05). The AUC of M2-PK, CEA and ADAM8 combined detection (0.924) was significantly higher than that of M2-PK, CEA and ADAM8 separate detection(0.731, 0.858 and 0.790),and the difference was statistically significant (P<0.05). The sensitivity and specificity of M2-PK, CEA and ADAM8 combined detection were significantly higher than those of M2-PK, CEA and ADAM8 separate detection (P<0.05). Conclusion The value of M2-PK, CEA and ADAM8 in diagnosing NSCLC has a certain clinical value, and the diagnostic value of M2-PK, CEA and ADAM8combined detection is superior to that of separate detection, and M2-PK, CEA and ADAM8 combined detection worthy of clinical application. |
| keywords:NSCLC M2-PK CEA ADAM8 |
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