| 肝纤维化4项在原发性肝癌放疗前后变化的意义 |
| 投稿时间：2016-12-25 修订日期：2017-02-02 点此下载全文 |
| 引用本文：高世乐,胡宗涛,董六一,周俊平,朱捷,费振乐,卢东徽,刘阳.肝纤维化4项在原发性肝癌放疗前后变化的意义[J].医学研究杂志,2017,46(11):153-156 |
| DOI：
10.11969/j.issn.1673-548X.2017.11.037 |
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| 中文摘要:目的 回顾性分析笔者医院72例原发性肝癌患者放疗前后肝纤维化4项指标的变化，探讨其与放射性肝损伤的演变关系。方法 检测原发性肝癌患者放疗前1天、放疗后2、4、8、12、26周血清中HA、LN、PCⅢ、CⅣ、AST、ALT、ALP、γ-GT、TBIL水平以及肝脏CT的动态变化。结果 放疗至第2周，部分患者血清肝纤维化4项水平开始升高，至第12周达峰值，第26周未再持续上升，且与转氨酶水平相比呈正相关，放疗后各时期测得指标同放疗前1天相比，差异有统计学意义（P<0.05或P<0.01）。结论 肝纤维化4项可作为放射性肝损伤的判定指标，尤其是早期肝纤维化的预测，为早期治疗提供实验室依据。 |
| 中文关键词:肝纤维化4项 转氨酶 原发性肝癌 放射性肝损伤 肝纤维化 |
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| The Significance of Four Liver Fibrosis in Primary Liver Cancer Before or after Radiotherapy |
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| Abstract:Objective Retrospectively analysis the changes of four hepatic fibrosis indexes before and after radiotherapy in 72 cases primary liver cancer in our hospital,to investigate the relationship between the changes of liver injury and radiation induced liver injury.Methods We detected the dynamic changes in serum HA,LN,PCⅢ,CⅣ,AST,ALT,ALP,γ-GT,TBIL and CT in liver before radiotherapy 1 day and after radiotherapy on 2,4,8,12,26 weeks about primary liver cancer patients.Results Some patients with serum liver fibrosis four levels began to rise after Radiotherapy 2 weeks,reach the peak on 12 weeks,continue to rise on 26 weeks,which had a positive correlation with the level of aminotransferase.compared with the 1 day before radiotherapy, the indexes after radiotherapy were P<0.05 or P<0.01,had statistical significance.Conclusion Four items of liver fibrosis can be used as a criterion for the determination of radiation induced liver injury,especially in the prediction of early liver fibrosis which, provides laboratory evidence for early treatment. |
| keywords:Four hepatic fibrosis Transaminase Primary liver cancer Radioactive liver injury Hepatic fibrosis |
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