| 气滞胃痛颗粒联合乌贝散治疗青年军人十二指肠溃疡的临床观察 |
| 投稿时间：2017-09-11 修订日期：2017-10-07 点此下载全文 |
| 引用本文：李涛,王泳,陆敏.气滞胃痛颗粒联合乌贝散治疗青年军人十二指肠溃疡的临床观察[J].医学研究杂志,2018,47(6):172-175,138 |
| DOI：
10.11969/j.issn.1673-548X.2018.06.040 |
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| 中文摘要:目的 观察气滞胃痛颗粒联合乌贝散治疗青年军人十二指肠球部溃疡（duodenal ulcer，DU）的疗效和安全性。方法 84例经胃镜和13C呼气试验确诊的非幽门螺杆菌感染的DU青年军人患者，随机分为治疗组40例，对照组44例。治疗组服用气滞胃痛颗粒和乌贝散，对照组服用埃索美拉唑镁肠溶片，共4周。记录治疗前后患者的中医症状评分，以及治疗期间出现的不良反应。治疗4周后复查胃镜，评估溃疡愈合疗效。结果 4周后，治疗组溃疡愈合率为87.5%，有效率为95.0%；对照组溃疡愈合率为86.4%，有效率为97.7%，组间差异无统计学意义（Z=0.074，P>0.05）。治疗组临床症状改善有效率为95.0%，对照组为88.6%，组间差异无统计学意义（Z=0.793，P>0.05）。经过治疗，两组胃脘痛、腹胀嗳气和嘈杂反酸等单项临床症状均得以良好改善，组间差异无统计学意义（P>0.05）；但是治疗组胸闷太息、烦躁易怒和口苦食欲不振等症状的改善明显优于对照组，组间差异有统计学意义（P<0.05）。两组间不良反应发生率分别为15%、13.6%，差异无统计学意义（χ2=0.01，P>0.05）。结论 气滞胃痛颗粒联合乌贝散治疗青年军人非幽门螺杆菌感染DU安全有效，其疗效和埃索美拉唑镁肠溶片相近。与埃索美拉唑镁肠溶片相比，还可显著改善溃疡相关的精神及全身症状。 |
| 中文关键词:气滞胃痛颗粒 乌贝散 中药 埃索美拉唑 十二指肠球部溃疡 |
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| Treatment of Qizhi Weitong Granule plus Wubei Powder in Army Men with Helicobacter Pylori Negative Duodenal Ulcer Disease |
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| Abstract:Objective To evaluate the effect and safety of Qizhi Weitong Granule plus Wubei Powder in treatment of army men with helicobacter pylori negative duodenal ulcer disease. Methods A randomized,single-blind,controlled study was conducted in 84 army men with helicobacter pylori negative duodenal ulcer disease.They were randomly divided into trial group(n=40,Qizhi Weitong Granule plus Wubei Powder were administered daily for 4 weeks)and control group(n=44,they took imported esomeprazole daily for 4 weeks).Symptoms and adverse reactions were recorded.Gastroscopy was performed by the end of the fourth week. Results After treatment,the cure rate and total effective healing rate of ulcer were 87.5%and 95.0% in trial group,and those in control group were 86.4% and 97.7% respectively.The difference was not statistically significant(Z=0.074.P>0.05).The relief rates of symptoms were 95.0% in trial group and 88.6% in control group, the difference was not of statistical significance (Z=0.793,P>0.05).There was no statistically significant difference in the relief of gastric abscess,flatulence,belching and acid regurgitation between the two groups (P>0.05).But the symptoms of irritability and bad temper,chest distress and deep sighing,bitter taste in the mouth and poor appetite in trial group were improved more significantly than those in control group.The difference was statistically significant(P<0.05).The incidences of adverse reaction were 15% in trial group and 13.6% in control group,the difference was not statistically significant (χ2=0.01,P>0.05). Conclusion Qizhi Weitong Granule plus Wubei Powder is as effective,safe and well tolerated as imported esomeprazole in army men with helicobacter pylori negative duodenal ulcer disease.But Qizhi Weitong Granule plus Wubei Power can improve mental symptoms and appetite of patients with duodenal ulcer disease significantly. |
| keywords:Qizhi Weitong Granule Wubei Powder Chinese herbal medicine Esomeprazole Duodenal ulcer disease |
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